Understanding findings
Selected pre/post measurements moved in different directions. The pattern is exploratory and cannot show what caused the changes.
In the source report, a DNA-methylation pace-of-aging measure changed from 1.098 to 0.993 year per year (paired n=10; p=0.002). HbA1c changed from 42.7 to 40.4 mmol/mol (n=10; p=0.008). Timed Up and Go changed from 9.22 to 7.11 seconds (n=9; p=0.023), and measured body-fat percentage changed from 34.19% to 33.19% (n=7; p=0.016). These are pre/post associations from one small combined program.
The cognitive score changed from 25.7 to 26.9 points, but this was not statistically significant (n=10; p=0.32). Two broad biological-age estimates and telomere length were also approximately unchanged. One modeled lung-age subscore moved in an adverse direction. Positive results in some measures should not be generalized to every organ system or translated into years of life gained.
The evaluation was small, open-label and uncontrolled, tested many endpoints without multiplicity adjustment, and combined several interventions at once. Sample size differed across measures. A platform change required reconstruction of some baseline biological-age values. The findings are useful for feasibility and planning further research, but they do not establish causality, individual benefit or comparative effectiveness.
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